Mitopaths

Na+/Ca2+ exchange

Contributor: Saverio Marchi

{"name":"Na+\/Ca2+ exchange","theorem":{"head":{"_type":"conjunction","components":[{"_type":"molecule","name":"Na+","position":1},{"_type":"molecule","name":"Na+","position":1},{"_type":"molecule","name":"Na+","position":1},{"_type":"protein","name":"NCLX","position":2},{"_type":"molecule","name":"Ca2+","position":4}]},"body":{"_type":"conjunction","components":[{"_type":"molecule","name":"Na+","position":4},{"_type":"molecule","name":"Na+","position":4},{"_type":"molecule","name":"Na+","position":4},{"_type":"protein","name":"NCLX","position":2},{"_type":"molecule","name":"Ca2+","position":1}]}},"steps":[{"head":{"_type":"interaction","position":7,"components":[{"_type":"molecule","name":"Na+","position":4},{"_type":"molecule","name":"Na+","position":4},{"_type":"molecule","name":"Na+","position":4},{"_type":"protein","name":"NCLX","position":2},{"_type":"molecule","name":"Ca2+","position":1}]},"body":{"_type":"conjunction","components":[{"_type":"molecule","name":"Na+","position":4},{"_type":"molecule","name":"Na+","position":4},{"_type":"molecule","name":"Na+","position":4},{"_type":"protein","name":"NCLX","position":2},{"_type":"molecule","name":"Ca2+","position":1}]}},{"head":{"_type":"interaction","position":7,"components":[{"_type":"molecule","name":"Na+","position":1},{"_type":"molecule","name":"Na+","position":1},{"_type":"molecule","name":"Na+","position":1},{"_type":"protein","name":"NCLX","position":2},{"_type":"molecule","name":"Ca2+","position":4}]},"body":{"_type":"interaction","position":7,"components":[{"_type":"molecule","name":"Na+","position":4},{"_type":"molecule","name":"Na+","position":4},{"_type":"molecule","name":"Na+","position":4},{"_type":"protein","name":"NCLX","position":2},{"_type":"molecule","name":"Ca2+","position":1}]}},{"head":{"_type":"conjunction","components":[{"_type":"molecule","name":"Na+","position":1},{"_type":"molecule","name":"Na+","position":1},{"_type":"molecule","name":"Na+","position":1},{"_type":"protein","name":"NCLX","position":2},{"_type":"molecule","name":"Ca2+","position":4}]},"body":{"_type":"interaction","position":7,"components":[{"_type":"molecule","name":"Na+","position":1},{"_type":"molecule","name":"Na+","position":1},{"_type":"molecule","name":"Na+","position":1},{"_type":"protein","name":"NCLX","position":2},{"_type":"molecule","name":"Ca2+","position":4}]}}]}

Theorem

Information

Mitochondrial NCLX (also known as SLC8B1), located at the inner membrane, catalyzes the Na+-dependent Ca2+ efflux out of the matrix. Ca2+ extrusion is electrogenic (3 or 4 Na+ ions for 1 Ca2+ ion).

References:

Palty R, Silverman WF, Hershfinkel M, Caporale T, Sensi SL, Parnis J, Nolte C, Fishman D, Shoshan-Barmatz V, Herrmann S, Khananshvili D, Sekler I. NCLX is an essential component of mitochondrial Na+/Ca2+ exchange. Proc Natl Acad Sci US A. 2010 Jan 5;107(1):436-41. doi: 10.1073/pnas.0908099107. Epub 2009 Dec 15. PMID: 20018762.

Takeuchi A, Kim B, Matsuoka S. The mitochondrial Na+-Ca2+ exchanger, NCLX, regulates automaticity of HL-1 cardiomyocytes. Sci Rep. 2013 Sep 26;3:2766. doi: 10.1038/srep02766. PMID: 24067497.

Kostic M, Sekler I. Functional properties and mode of regulation of the mitochondrial Na+/Ca2+ exchanger, NCLX. Semin Cell Dev Biol. 2019 Oct;94:59-65. doi: 10.1016/j.semcdb.2019.01.009. Epub 2019 Jan 30. PMID: 30658153.

Link to other Databases:

Reactome: https://reactome.org/content/detail/R-HSA-8949688